Lyme disease doesn’t just affect the body — it can also impact the brain and emotions, leading to noticeable personality changes. Many individuals suffering from Lyme disease, especially in chronic or late-stage cases, report symptoms such as increased irritability, anxiety, depression, mood swings, and even cognitive difficulties like brain fog or memory lapses. Combining medical treatment with holistic support—such as therapy, nutrition, mindfulness, and neuroinflammation-reducing practices—can help manage and improve mental health outcomes.