Untreated leg ulcers may become deeply infected, leading to complications such as gangrene, bone infections (osteomyelitis), and sepsis, which can all lead to amputation. Leg ulcers can also lead to significant tissue damage, scarring, and limb dysfunction. Prompt intervention is essential for maintaining your health. A venous ulcer is one of the more advanced complications of chronic venous insufficiency, a condition where the veins in your legs are no longer able to circulate blood effectively.