Download the list of Companies in South Carolina. Smartscrapers provides an accurate directory and the latest data on the number of Companies in South Carolina There are 43103 Companies in South Carolina as of April 1, 2026; which is an 0.00% increase from 2023. Of these locations, 38067 Companies which is 88.32% of all Companies in South Carolina are single-owner operations, while the remaining 5036 which is 11.68% are part of larger brands. The top three cities with the most Companies are Charleston with 3415 Companies, Orangeburg with 3412 Companies, Darlington with 2898 Companies. Average age of Companies in South Carolina is 4 years and 7 months.